2-Methyl-4-isothiazolin-3-one hydrochloride CAS:26172-54-3

2‑Methyl‑4‑isothiazolin‑3‑one hydrochloride (CAS 26172‑54‑3) is a water‑soluble solid compound with antimicrobial and antifungal properties. It is frequently employed in scientific investigations to assess its cytotoxic impacts on bronchial epithelial cells and its role in neural development. As a stabilized derivative of the biocidal substance methylisothiazolinone (MIT), it exerts its effects by disrupting protein synthesis, and is widely utilized as a preservative across industrial uses and personal care formulations.

Product Details

Core Characteristics

CAS Registry Number: 26172-54-3
Chemical Features: Solid state, melting point between 165–170°C, with excellent water solubility exceeding 400g/L.

Research Applications

Serves as a cytotoxic substance in laboratory studies, commonly applied in research on cell apoptosis, for instance in experiments involving BEAS-2B cells.


2-Methyl-4-isothiazolin-3-one hydrochloride CAS:26172-54-3


Safety Warnings

Classified as a potent sensitizer; allergic responses linked to methylisothiazolinone (MIT) have resulted in regulatory limitations on cosmetic applications, with approval mainly limited to rinse-off products.

Typical Uses

  • Antimicrobial Substance: Utilized in scientific research for its bactericidal and fungicidal capabilities.

  • Industrial Preservative: Widely added to water-based products including adhesives to inhibit spoilage and deterioration.

  • Analytical Reference Material: Used as a standard in HPLC and other chromatographic methods for product detection and analysis.

Safety & Handling Guidelines

  • Allergenic Risk: As a highly effective biocide, it may trigger contact dermatitis upon exposure.

  • Operational Safety: Due to its inherent biocidal properties, cautious operation and proper protection are required during use.


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