Gentamicin sulfateCAS：1405-41-0
Broad-Range Antibacterial Efficacy: Exhibits potent activity against Gram-negative bacterial strains, such as Escherichia coli, various Shigella isolates, and Pseudomonas aeruginosa.
Diverse Clinical Utility: Utilized in the treatment of systemic infections, localized lesions, ophthalmic conditions, and intestinal infectious diseases. Additionally, it serves as a preoperative preventive measure for colorectal surgical procedures.
Synergistic Combination Regimens: When co-administered with metronidazole or clindamycin, it achieves enhanced protection against postoperative infections, optimizing therapeutic outcomes.
Stability and Reliable Performance: Retains its chemical stability in aqueous formulations at 37°C for a maximum duration of 5 days, guaranteeing consistent and trustworthy therapeutic effects throughout the treatment course.
Gentamicin sulfate belongs to the aminoglycoside family of bactericidal antibiotics, characterized by a molecular structure consisting of amino sugar moieties and ligand components. As the sulfate salt form of gentamicin, this agent shares a comparable antimicrobial spectrum with kanamycin. Clinically, it is mainly employed in the management of systemic and localized infections induced by Gram-negative pathogenic bacteria, including Escherichia coli, Shigella dysenteriae, Klebsiella pneumoniae, Proteus spp., and Pseudomonas aeruginosa. Within ophthalmology, its indications encompass common conditions such as conjunctivitis and keratitis.
Parameters
Melting point | 218-237°C |
alpha | D25 +102° |
density | 1.000 g/cm3 |
storage temp. | 2-8°C |
solubility | H2O: 50 mg/mL As stock solution, store at −20°C. Stable at 37°C for 5 days. |
form | |
color | colorless to light yellow |
Odor | odorless |
PH | 4.0-5.5 (0.1g/mL in H2O) |
optical activity | [α]20/D +110±8°, c = 1% in H2O |
biological source | Micromonospora purpurea |
Water Solubility | Soluble in water |
Merck | 134403 |
InChIKey | RDEIXVOBVLKYNT-HDZPSJEVSA-N |
CAS DataBase Reference | 1405-41-0(CAS DataBase Reference) |
EPA Substance Registry System | Gentamicin sulfate (1405-41-0) |
Safety Information | |
Hazard Codes | Xn |
Risk Statements | 42/43 |
Safety Statements | 23-36/37-45-22-24/25 |
WGK Germany | 2 |
RTECS | LY2625000 |
F | 3 |
HS Code | 29419010 |
Toxicity | LD50 in mice (mg base/kg): 430 i.p.; 485 s.c.; 75 i.v.; >9050 orally (Black) |
For the management of intestinal infectious diseases or preoperative bowel preparation prior to colorectal surgical interventions, gentamicin sulfate can be delivered through the oral administration route. Moreover, when combined with metronidazole or clindamycin, this antibiotic exhibits significant effectiveness in lowering the incidence of postoperative infections subsequent to colon-related surgical procedures.
