Pyridoxine hydrochlorideCAS:58-56-0


Vitamin B6 acts as a key coenzyme involved in amino acid metabolism and neurotransmitter synthesis, which helps maintain the normal operation of overall human metabolism.

Prevention of Nutritional Deficiency and Adverse Symptoms:

It can effectively lower the risk of nutritional deficiency-related diseases including pellagra. Meanwhile, it is able to relieve morning sickness during pregnancy, vomiting caused by radiotherapy, as well as discomfort symptoms induced by drug toxicity.

Maintenance of Nervous System Function:

Vitamin B6 plays an irreplaceable role in preserving the physiological health of the nervous system and alleviating neurological abnormalities caused by nutrient shortage.

Physicochemical Properties and Application Characteristics:

This vitamin features good stability at room temperature and is readily soluble in water and ethanol. Such properties enable it to maintain stable efficacy and be widely applied in a variety of pharmaceutical preparations.


Product Details
Vitamin B6, commonly referred to as pyridoxine or the anti-pellagra factor, is chemically defined as 2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine. Its commonly used pharmaceutical grade is usually provided in the form of pyridoxine hydrochloride, which serves as the primary form adopted in clinical and medicinal products.


This substance appears as a white to pale yellow crystalline powder, with a decomposition temperature ranging from 204 to 206°C. It is highly soluble in water, ethanol and acetone, but only slightly soluble in diethyl ether. It has an acidic and bitter taste, remains stable under ordinary environmental conditions, yet will slowly degrade when exposed to light and possesses sublimation properties.


Pyridoxine hydrochlorideCAS:58-56-0



Melting point 

214-215 °C(lit.)

density 

1.2784 (rough estimate)

vapor density 

7.1 (vs air)

refractive index 

1.5800 (estimate)

Fp 

9℃

storage temp. 

room temp

solubility 

H2O: 0.1 g/mL at 20 °C, clear, colorless

form 

Crystalline Powder

color 

White to almost white

PH Range

3.2

biological source

synthetic (organic)

Water Solubility 

0.1 g/mL (20 ºC)

Sensitive 

Light Sensitive

Merck 

147982

BRN 

3632435

BCS Class

1

Stability:

Stable. Protect from air and light.

LogP

-1.098 (est)

CAS DataBase Reference

58-56-0(CAS DataBase Reference)

EPA Substance Registry System

5-Hydroxy-6-methyl-3,4-pyridinedimethanol, hydrochloride (58-56-0)

Safety Information


Hazard Codes 

Xi,T,F

Risk Statements 

36/37/38-39/23/24/25-23/24/25-11

Safety Statements 

26-37/39-45-36/37-16-7-24/25

RIDADR 

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 

2

RTECS 

UV1350000

45879

TSCA 

Yes

HS Code 

29362500

Hazardous Substances Data

58-56-0(Hazardous Substances Data)



Pyridoxine hydrochlorideCAS:58-56-0


Upon reaction with ferric chloride solution, this compound generates a distinct reddish-brown chromogenic reaction, which serves as one of its characteristic identification features. 


Naturally occurring vitamin B6 can be isolated from multiple sources, including rice bran, plant materials, yeast, molasses and lipid-rich substances. At present, its industrial synthesis mainly employs methyl methoxyacetate, acetone and ethyl cyanoacetate as key starting materials. 


In clinical practice, it is widely used for the prevention and treatment of pregnancy-related vomiting, radiation sickness-induced nausea, isoniazid poisoning, as well as gastrointestinal adverse reactions caused by antitumor drugs. In addition, it can be used as an adjuvant therapeutic agent for pellagra and certain other nutritional deficiency disorders.


Pyridoxine hydrochlorideCAS:58-56-0


When mixed with ferric chloride reagent, this compound yields a distinctive reddish‑brown color. Naturally, it can be found in rice bran, plant material, yeast extracts, molasses, and fatty substances. For synthetic production, starting materials such as methyl methoxyacetate, acetone, and ethyl cyanoacetate are employed.


In clinical practice, it is used to prevent and treat nausea during pregnancy, vomiting resulting from radiation therapy, isoniazid poisoning, and gastrointestinal side effects caused by anticancer drugs. Additionally, it serves as a supplementary treatment for pellagra and certain conditions arising from nutritional deficiencies.


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