Sodium hyaluronate CAS：9067-32-7
Excellent biocompatibility and non-irritating nature – derived from substances that exist naturally in the human body, it greatly reduces inflammatory reactions.
Outstanding viscoelastic performance – features high viscosity and elasticity, ideal for application in medical and surgical procedures.
Extreme purity and sterility – with a protein level below 0.5%, Healon complies with strict medical-grade purity and biocompatibility requirements.
Smooth injectability with fine needles – its adaptable molecular structure allows effortless delivery through ultra-fine needles, improving usability in clinical practice.
Sodium hyaluronate, often referred to as sodium glycosaminoglycan, is a natural biological macromolecule abundantly found in human tissues.
Classified as a high-molecular-weight linear mucopolysaccharide polymer, it consists of repeated disaccharide structures formed by glucuronic acid and acetylated hexosamine, with an average molecular weight of around 1,000,000.
When dissolved in water, it creates a highly viscoelastic solution whose pH and ion environment are highly consistent with human body fluids.
Its pliable molecular structure allows for smooth injection using fine needles.
A purified, non-irritating grade of sodium hyaluronate is commercially supplied under the brand Healon.
When prepared in normal saline at a concentration of 10 mg/mL, Healon reaches a viscosity nearly 200,000 times higher than aqueous humor or pure saline solution.
With protein content controlled below 0.5%, it guarantees exceptional purity and sterility required for clinical and medical applications.
Parameters
| Parameter | Specification |
| CAS No. | 9067-32-7 |
| Product Name | Sodium Hyaluronate (Hyaluronic Acid Sodium Salt) |
| Melting Point | >209°C (Decomposition) |
| Specific Rotation [α]D | -74° (c = 0.25, H₂O), Reference: Rapport et al., J. Am. Chem. Soc. 73, 2416 (1951) |
| Storage Condition | -20°C (Freeze & Seal) |
| Solubility (in Water) | 5 mg/mL, forming a clear, colorless solution |
| Physical Form | Powder |
| Color | White to Creamy White |
| pH Value (2g/L, 25°C) | 5.5 ~ 7.5 |
| Biological Source | Chicken Comb (Rooster Comb) / Fermentation-derived |
| Water Solubility | Freely Soluble |
| Merck Index No. | 13, 4776 |
| Stability | Stable; Incompatible with strong oxidizing agents |
| InChI | 1/C14H23NO11.Na/c1-4(17)15-5-2-6(18)7-3(16)24-14(5)26-10-8(19)9(20)13(23)25-11(10)12(21)22;/h5-11,13-14,16,18-20,23H,2-3H2,1H3,(H,15,17)(H,21,22)/q;+1/p-1/t5-,6+,7-,8-,9-,10+,11+,13-,14+;/s3 |
| InChIKey | MAKUBRYLFHZREJ-JWBQXVCJSA-M |
| SMILES | [C@@H]1(O[C@H]2C@HC@HO)OC@HC@@HC[C@H]1NC(=O)C.[Na+] |
| LogP (Est.) | -6.623 |
Safety Information
| Hazard Codes | B, Xi (Irritant) |
| Risk Statements (R-phrases) | 36/37/38 (Irritating to eyes, respiratory system and skin) |
| Safety Statements (S-phrases) | 22-24/25-36/37/39-27-26 |
| WGK (Germany Water Hazard Class) | 3 (Strongly hazardous to water) |
| RTECS Number | MT7250000 |
| Flash Point (F) | 3-10°C |
| HS Code | 39139000 |
| Toxicity | LD50 oral in rabbit: > 1 g/kg |
