FluconazoleCAS：86386-73-4
Broad-Spectrum Antifungal Activity: Fluconazole exhibits extensive antifungal efficacy against both systemic and superficial fungal infections, rendering it suitable for a wide range of therapeutic applications.
Selective Enzyme Inhibition: This compound selectively targets fungal cytochrome P-450-dependent lanosterol 14α-demethylase, thereby disrupting ergosterol biosynthesis—a process critical for maintaining the structural integrity of fungal cell membranes.
Ergosterol Biosynthesis Interference: By suppressing key enzymatic steps in fungal sterol synthesis, Fluconazole effectively impairs membrane stability and compromises fungal survival capacity.
Clinical Reliability: Distinguished by its targeted mechanism of action and consistent therapeutic effectiveness, Fluconazole has emerged as a well-established first-line agent for the management of fungal infections.
Fluconazole, a triazole-class antifungal agent initially developed by Pfizer, possesses broad-spectrum activity against systemic fungal infections. It exerts its therapeutic effects through the selective inhibition of fungal cytochrome P-450-dependent enzymes—most notably lanosterol 14-α-demethylase—thereby disrupting ergosterol biosynthesis, a process indispensable for maintaining the structural integrity of fungal cell membranes.
Pharmacological Properties
Broad-Spectrum Antifungal Activity: Fluconazole exhibits extensive antifungal efficacy against both systemic and superficial fungal infections, rendering it suitable for a wide range of therapeutic applications.
Selective Enzyme Inhibition: This compound selectively targets fungal cytochrome P-450-dependent lanosterol 14α-demethylase, disrupting ergosterol biosynthesis—a critical process for fungal cell membrane stability.
Sterol Synthesis Suppression: By inhibiting key enzymatic steps in fungal sterol metabolism, Fluconazole further enhances its antifungal potency and compromises fungal viability.
Clinical Reliability: Distinguished by its targeted mechanism of action and consistent therapeutic performance, Fluconazole has emerged as a clinically established agent for the management of diverse fungal pathologies.
Key Physical & Chemical Parameters
Parameter | Details |
Melting Point | 138-140°C |
Boiling Point | 579.8±60.0 °C (Predicted) |
Density | 1.05 |
Flash Point (Fp) | 9℃ |
Storage Temperature | 2-8°C |
Solubility | DMSO: 5 mg/mL; Water Solubility: 1g/L (temperature not stated) |
Form | Solid |
pKa | 1.76±0.1 (H₂O, t=24, I=0.1(NaCl)) (Uncertain) |
Color | White to Off-White |
Merck Index | 144122 |
BCS Class | 1, 3 |
InChI | InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 |
InChIKey | RFHAOTPXVQNOHP-UHFFFAOYSA-N |
SMILES | C1(C=CC(F)=CC=1F)C(O)(CN1N=CN=C1)CN1N=CN=C1 |
CAS Database Reference | 86386-73-4 |
Safety Information
Hazard Codes: Xn, Xi, T, F
Risk Statements: 22-36/37/38-20/21/22-39/23/24/25-23/24/25-11
Safety Statements: 26-36-36/37/39-24/25-45-36/37-16-7
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 3
RTECS: XZ4810000
HS Code: 29336990
Hazardous Substances Data: 86386-73-4 (Hazardous Substances Data)
